Advanced search×

Validation of noninvasive diagnosis of BK virus nephropathy and identification of prognostic biomarkers.

Darshana D Dadhania, Catherine C Snopkowski, Ruchuang R Ding, Thangamani T Muthukumar, Jun J Lee, Heejung H Bang, Vijay K VK Sharma, Surya S Seshan, Phyllis P August, Sandip S Kapur, and Manikkam M Suthanthiran

Transplantation 90(2):189-97 (2010) PMID 20526237

BK virus nephropathy (BKVN) may cause renal allograft dysfunction and failure. The gold standard test is kidney biopsy, which is invasive and costly. A noninvasive, accurate biomarker for diagnosis of BKVN and prognostication of allograft function after BKVN infection may improve allograft survival.

DOI: 10.1097/TP.0b013e3181e2a932
Version: za2963e q8zae q8zb9 q8zc9 q8zd4 q8zeb q8zfa q8zgb
View PDF

Similar articles you may find interesting…

  1. Methionine oxidation activates a transcription factor in response to oxidative stress.
    Adrian Drazic, Haruko Miura, and Jeannette Winter

    Proc Natl Acad Sci U S A (2013) PMID 23690622

    We unravel that HypT is activated by methionine oxidation to methionine sulfoxide. Interestingly, so far only inactivation of cellular proteins by methionine oxidation has been reported. Mutational analysis revealed three methionines that are essential to confer HOCl resistance. Their simultaneous s...
  2. Genetic Mediators of Neurocognitive Outcomes in Survivors of Childhood Acute Lymphoblastic Leukemia.
    Kevin R Krull, Deepa Bhojwani, and Ching-Hon Pui

    J Clin Oncol (2013) PMID 23650422

    PURPOSESurvivors of childhood acute lymphoblastic leukemia (ALL) are at increased risk for neurocognitive problems, with significant interindividual variability in outcome. This study examined genetic polymorphisms associated with variability in neurocognitive outcome. PATIENTS AND M...
  3. Mechanism of endogenous regulation of the type I interferon response by Suppressor of IKK{epsilon} (SIKE), a novel substrate of TANK binding...
    James D Marion, Charlotte F Roberts, and Jessica K Bell

    J Biol Chem (2013) PMID 23649622

    We describe the mechanism by which Suppressor of IKKε (SIKE) inhibits TBK1-mediated phosphorylation of interferon regulatory factor 3 (IRF3), essential to type I interferon production. Kinetic analyses showed that SIKE not only inhibits IRF3 phosphorylation, but is also a high-affinity, TBK1 substr...
    PDF not found