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ABCB1/MDR1 gene polymorphisms as a prognostic factor in colorectal cancer.

Ewa E Balcerczak, Mariusz M Panczyk, Sylwester S Piaskowski, Grazyna G Pasz-Walczak, Aleksandra A Sałagacka, and Marek M Mirowski

Int J Colorectal Dis 25(10):1167-76 (2010) PMID 20533057

To analyse the single-nucleotide polymorphisms (SNPs): ABCB1(1236C>T), ABCB1(2677G>T/A), ABCB1(3435C>T) and haplotypes in the ABCB1/MDR1 gene, which could contribute to genetic risk of colorectal cancer (CRC). Disease association between the ABCB1/MDR1 genotype, allele, haplotype frequencies and histological features, such as TNM classification, localization of primary carcinoma, grade of malignancy, histological type of tumour, lymphoid infiltration and vessel invasion were estimated. In this study, the potential role of SNPs of the ABCB1/MDR1 gene as a prognostic marker for CRC was analysed.

DOI: 10.1007/s00384-010-0961-2
Version: za2963e q8za3 q8zbd q8zc4 q8zd2 q8ze1 q8zff q8zgf

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