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Cut-offs for screening prolonged QT intervals from Fridericia's formula in children and adolescents.

Daisuke D Hazeki, Masao M Yoshinaga, Hideto H Takahashi, Yuji Y Tanaka, Yasue Y Haraguchi, Mayumi M Abe, Masami M Koga, Toshiro T Fukushige, and Masami M Nagashima

Circ J 74(8):1663-9 (2010) PMID 20534944

The corrected QT interval (QTc) according to Bazett's formula (QTc = QT/RR(1/2)) has been used in clinical practice. Bazett's formula, however, overcorrects the QT interval at fast heart rates and undercorrects it at low heart rates. Guidelines and some investigators have recommended using Fridericia's formula (QTc = QT/RR(1/3)) in these cases, especially in tachycardic subjects. The aim of the present study was to determine cut-offs for QTc suitable for screening pediatric subjects with prolonged QT intervals, based on manually measured values corrected by Fridericia's formula in a large number of subjects.

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