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Amino/guanidino-functionalized N-(pyrrolidin-2-ethyl)glycine-based pet-PNA: design, synthesis and binding with DNA/RNA.

Sachin S SS Gokhale and Vaijayanti A VA Kumar

Org Biomol Chem 8(16):3742-50 (2010) PMID 20539879

The N-(pyrrolidin-2-ethyl) glycine-based PNA (pet-PNA) backbone, with 4-amino or 4-guanidino-functionalized pyrrolidine ring, confers constrained conformational flexibility on aegPNA. The oligomers bind to the target DNA and RNA sequences with increased sequence specificity and antiparallel versus parallel orientation selectivity. The easy post-synthetic guanidination gives very good access to the positively charged PNA oligomers.

DOI: 10.1039/c004005c
Version: za2963e q8zab q8zb0 q8zc2 q8zd3 q8ze3 q8zf9 q8zg6

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