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Lignan and neolignan glycosides from the roots of Glehnia littoralis.

Yi Y Xu, Xue X Gu, and Zhong Z Yuan

Planta Med 76(15):1706-9 (2010) PMID 20560111

A new lignan glycoside [glehlinoside G (1)] and three new neolignan glycosides [glehlinosides H (2), I (3) and J (4)] were isolated from the roots of Glehnia littoralis. Their structures were elucidated on the basis of spectroscopic data. The above glehlinosides (1-4), together with the other lignan and neolignan glycosides (5-12) from this plant, were evaluated for their prolyl oligopeptidase inhibitory activities, and a caffeoyled lignan glycoside (glehlinoside F, 8) exhibited a noticeable activity (IC(50) = 14.5 µM).

DOI: 10.1055/s-0030-1250044
Version: za2963e q8za2 q8zbc q8zcb q8zda q8ze8 q8zf3 q8zg4

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