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ADAM-17: a target to increase chemotherapeutic efficacy in colorectal cancer?

Adam M AM Lee and Robert B RB Diasio

Clin Cancer Res 16(13):3319-21 (2010) PMID 20570925

Chemotherapy-induced activation of ADAM-17 results in increased growth factor shedding and activation of growth factor receptor-mediated pro-survival response. Enhanced ADAM-17 activity and HER ligand shedding results in resistance to chemotherapy in CRC. Therapies that decrease ADAM-17 activity in conjunction with current treatments may enhance response rates in advanced CRC patients.

DOI: 10.1158/1078-0432.CCR-10-1059
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