Advanced search×

Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration?

Maarten E Witte, Jeroen JG Geurts, Helga E de Vries, Paul van der Valk, and Jack van Horssen

Mitochondrion 10(5):8 (2010) PMID 20573557

Dysfunctional mitochondria are thought to play a cardinal role in the pathogenesis of various neurological disorders, such as multiple sclerosis, Alzheimer's disease, Parkinson's disease and stroke. In addition, neuroinflammation is a common denominator of these diseases. Both mitochondrial dysfunction and neuroinflammatory processes lead to increased production of reactive oxygen species (ROS) which are detrimental to neurons. Therefore, neuroinflammation is increasingly recognized to contribute to processes underlying neurodegeneration. Here we describe the involvement of mitochondrial (dys)function in various neurological disorders and discuss the putative link between mitochondrial function and neuroinflammation.

Copyright © 2010 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.mito.2010.05.014
Version: za2963e q8za9 q8zbd q8zc3 q8zd6 q8ze4 q8zf8 q8zg2

Similar articles you may find interesting…

  1. Mitochondria and the Link Between Neuroinflammation and Neurodegeneration.
    Massimiliano Di Filippo, Davide Chiasserini, ... Paolo Calabresi

    J Alzheimers Dis (2010) PMID 20463396

    We describe the mechanisms by which neuroinflammation and mitochondrial impairment may synergistically trigger a vicious cycle ultimately leading to neuronal death. In particular, we will describe the close relationship existing among neuroinflammation, neurodegeneration, and mitochondrial impairmen...
  2. Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to...
    Gijs G Kooij, Mark R MR Mizee, ... Helga E HE de Vries

    Brain 134(Pt 2):555-70 (2011) PMID 21183485

    We investigated the expression pattern of different adenosine triphosphate-binding cassette efflux transporters, including P-glycoprotein, multidrug resistance-associated proteins-1 and -2 and breast cancer resistance protein in various well-characterized human multiple sclerosis lesions. Cerebrovas...
  3. Functionalized nanosystems for targeted mitochondrial delivery.
    Shelley A SA Durazo and Uday B UB Kompella

    Mitochondrion 12(2):190-201 (2012) PMID 22138492

    Mitochondrial dysfunction including oxidative stress and DNA mutations underlies the pathology of various diseases including Alzheimer's disease and diabetes, necessitating the development of mitochondria targeted therapeutic agents. Nanotechnology offers unique tools and materials t...