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Accumulation of L-type bovine prions in peripheral nerve tissues.

Yoshifumi Y Iwamaru, Morikazu M Imamura, Yuichi Y Matsuura, Kentaro K Masujin, Yoshihisa Y Shimizu, Yujing Y Shu, Megumi M Kurachi, Kazuo K Kasai, Yuichi Y Murayama, Shigeo S Fukuda, Sadao S Onoe, Ken'ichi K Hagiwara, Yoshio Y Yamakawa, Tetsutaro T Sata, Shirou S Mohri, Hiroyuki H Okada, and Takashi T Yokoyama

Emerg Infect Dis 16(7):1151-4 (2010) PMID 20587193 PMCID PMC3321908

We recently reported the intraspecies transmission of L-type atypical bovine spongiform encephalopathy (BSE). To clarify the peripheral pathogenesis of L-type BSE, we studied prion distribution in nerve and lymphoid tissues obtained from experimentally challenged cattle. As with classical BSE prions, L-type BSE prions accumulated in central and peripheral nerve tissues.

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