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Macromolecular and dendrimer-based magnetic resonance contrast agents.

Ambika A Bumb, Martin W MW Brechbiel, and Peter P Choyke

Acta radiol 51(7):751-67 (2010) PMID 20590365

Magnetic resonance imaging (MRI) is a powerful imaging modality that can provide an assessment of function or molecular expression in tandem with anatomic detail. Over the last 20-25 years, a number of gadolinium-based MR contrast agents have been developed to enhance signal by altering proton relaxation properties. This review explores a range of these agents from small molecule chelates, such as Gd-DTPA and Gd-DOTA, to macromolecular structures composed of albumin, polylysine, polysaccharides (dextran, inulin, starch), poly(ethylene glycol), copolymers of cystamine and cystine with GD-DTPA, and various dendritic structures based on polyamidoamine and polylysine (Gadomers). The synthesis, structure, biodistribution, and targeting of dendrimer-based MR contrast agents are also discussed.

DOI: 10.3109/02841851.2010.491091
Version: za2963e q8za8 q8zbc q8zc6 q8zd7 q8ze1 q8zf6 q8zg4
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