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A seven-gene set associated with chronic hypoxia of prognostic importance in hepatocellular carcinoma.

Hannah H van Malenstein, Olivier O Gevaert, Louis L Libbrecht, Anneleen A Daemen, Joke J Allemeersch, Frederik F Nevens, Eric E Van Cutsem, David D Cassiman, Bart B De Moor, Chris C Verslype, and Jos J van Pelt

Clin Cancer Res 16(16):4278-88 (2010) PMID 20592013

Hepatocellular carcinomas (HCC) have an unpredictable clinical course, and molecular classification could provide better insights into prognosis and patient-directed therapy. We hypothesized that in HCC, certain microenvironmental regions exist with a characteristic gene expression related to chronic hypoxia which would induce aggressive behavior.

DOI: 10.1158/1078-0432.CCR-09-3274
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