Advanced search×

Lipidomics: coming to grips with lipid diversity.

Andrej Shevchenko and Kai Simons

Nat Rev Mol Cell Biol 11(8):593-8 (2010) PMID 20606693

Although lipids are biomolecules with seemingly simple chemical structures, the molecular composition of the cellular lipidome is complex and, currently, poorly understood. The exact mechanisms of how compositional complexity affects cell homeostasis and its regulation also remain unclear. This emerging field is developing sensitive mass spectrometry technologies for the quantitative characterization of the lipidome. Here, we argue that lipidomics will become an essential tool kit in cell and developmental biology, molecular medicine and nutrition.

DOI: 10.1038/nrm2934
Version: za2963e q8za2 q8zb9 q8zcf q8zdd q8ze4 q8zf0 q8zg2
Buy PDF

Similar articles you may find interesting…

  1. Conflicting roles for a cell surface modification in Salmonella.
    John F May and Eduardo A Groisman

    Mol Microbiol (2013) PMID 23646936

    We address this question by examining the role of regulated variations in O-antigen length in the lipopolysaccharide (LPS), a glycolipid that forms most of the outer leaflet of the outer membrane in Gram-negative bacteria. We determined that activation of the PmrA/PmrB two-component system, which is...
    Buy PDF
  2. Surface Analysis of Lipids by Mass Spectrometry: More than Just Imaging.
    Shane R Ellis, Simon H Brown, and Todd W Mitchell

    Prog Lipid Res (2013) PMID 23623802

    We describe the current state-of-the-art in the direct surface analysis of lipids with a focus on tissue sections, intact cells and thin-layer chromatography substrates. The suitability of these different approaches towards analysis of the major lipid classes along with their current and potential a...
    Buy PDF
  3. Microbiomes.
    Karen E Nelson

    Microb Ecol (2013) PMID 23604403

    We get a perspective on where the science is headed and what we expect to learn as additional studies unfold....
    Buy PDF