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The effect of maternal subclinical hypothyroidism during pregnancy on brain development in rat offspring.

Dijie Liu, Weiping Teng, Zhongyan Shan, Xiaohui Yu, Yun Gao, Sen Wang, Chenling Fan, Hong Wang, and Hongmei Zhang

Thyroid 20(8):909-15 (2010) PMID 20615128

Maternal thyroid hormones (THs), especially thyroxine (T(4)), are crucial to early brain development in the mammalian embryo. Epidemiological studies and case reports have shown that maternal subclinical hypothyroidism may result in significant negative effects on pregnancy and neurodevelopment of the fetus. To understand the mechanism responsible for these neurological alterations, we induced maternal subclinical hypothyroidism in pregnant rats. Behavior and several genes that are under the control of THs were evaluated in the offspring of TH-deficient rats.

DOI: 10.1089/thy.2009.0036
Version: za2963e q8zaf q8zb7 q8zc7 q8zde q8ze8 q8zfa q8zgf

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