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Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant.

Hendrik H Dietrich and François F Jenck

Psychopharmacology (Berl) 212(2):145-54 (2010) PMID 20631993 PMCID PMC2937139

Orexins play a key role in the maintenance of alertness and are implicated in the modulation of diverse physiological processes, including cognitive function. Almorexant, a dual orexin receptor antagonist, transiently and reversibly blocks the action of orexin peptides at both OX(1) and OX(2) receptors and increases time spent in rapid eye movement (REM) and non-REM sleep.

DOI: 10.1007/s00213-010-1933-5
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