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Inflammasome inhibition as a pathogenic stealth mechanism.

Debra J DJ Taxman, Max T-H MT Huang, and Jenny P-Y JP Ting

Cell Host Microbe 8(1):7-11 (2010) PMID 20638636

The activation of inflammasomes containing NBD-LRR (NLRs) or non-NLRs is critical for effective host defense against microbial pathogens. Recent discoveries have uncovered a plethora of pathogenic strategies to inhibit inflammasome-mediated processing of IL-1beta and IL-18. We review recent evidence for viral and bacterial manipulation of the inflammasome, ranging from perturbation of caspase-1 activation to targeting of specific inflammasome components.

Copyright © 2010 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.chom.2010.06.005
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