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Evaluating diabetes and hypertension disease causality using mouse phenotypes.

Hong H Yu, Jialiang J Huang, Nan N Qiao, Christopher D CD Green, and Jing-Dong J JD Han

BMC Syst Biol (2010) PMID 20642857

Genome-wide association studies (GWAS) have found hundreds of single nucleotide polymorphisms (SNPs) associated with common diseases. However, it is largely unknown what genes linked with the SNPs actually implicate disease causality. A definitive proof for disease causality can be demonstration of disease-like phenotypes through genetic perturbation of the genes or alleles, which is obviously a daunting task for complex diseases where only mammalian models can be used.

DOI: 10.1186/1752-0509-4-97
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