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Perturbation of lamellar granule secretion by sodium caprate implicates epidermal tight junctions in lamellar granule function

Journal of Dermatological Science 59(2):107 (2010) PMID 20654784

Background Polarized secretion of lamellar granules (LGs) delivers various lipids, proteases, and protease inhibitors into the stratum corneum (SC) of the epithelium. Disruption of LGs is associated with severe cutaneous diseases, but the mechanism of their polarized secretion is not known. On the other hand, recent study shows epidermal tight junctions (TJs) localize in stratum granulosum (SG), and TJs are involved in polarized molecule secretion. Thus, we hypothesized epidermal TJs relate to polarized LGs secretion.

DOI: 10.1016/j.jdermsci.2010.06.001