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Sporadic inclusion body myositis: possible pathogenesis inferred from biomarkers.

Conrad C CC Weihl and Alan A Pestronk

Curr Opin Neurol 23(5):482-8 (2010) PMID 20664349

The relevance of proteins that accumulate and aggregate in the muscle fibers of patients with sporadic inclusion body myositis (sIBM) is unknown. Many of these proteins also aggregate in other disorders, including Alzheimer's disease, leading to speculation that sIBM pathogenesis has similarities to neurodegenerative disorders. Our review will discuss current studies on these protein biomarkers and their utility in sIBM diagnosis.

DOI: 10.1097/WCO.0b013e32833d3897
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