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Quantitative trait locus mapping of gravitaxis behaviour in Drosophila melanogaster.

Christie E Desroches, Macarena Busto, Craig A L Riedl, Trudy F C Mackay, and Marla B Sokolowski

Genet Res (Camb) 92(3):167-74 (2010) PMID 20667161

Drosophila melanogaster, like other organisms, move and orient themselves in response to the earth's gravitational force. The ability to sense and respond to gravity is essential for an organism to navigate and thrive in its environment. The genes underlying this behaviour in Drosophila remain elusive. Using 88 recombinant inbred lines, we have identified four quantitative trait loci (QTLs) that contribute to adult gravitaxis (geotaxis) behaviour in Drosophila. Candidate genes of interest were selected from the QTLs of highest significance based on their function in chordotonal organ formation. Quantitative complementation tests with these candidate genes revealed a role for skittles in adult gravitaxis behaviour in D. melanogaster.

DOI: 10.1017/S0016672310000194
Version: za2963e q8za4 q8zba q8zcf q8zd2 q8zeb q8zf0 q8zg8
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