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Dopaminergic network differences in human impulsivity.

Joshua W JW Buckholtz, Michael T MT Treadway, Ronald L RL Cowan, Neil D ND Woodward, Rui R Li, M Sib MS Ansari, Ronald M RM Baldwin, Ashley N AN Schwartzman, Evan S ES Shelby, Clarence E CE Smith, Robert M RM Kessler, and David H DH Zald

Science 329(5991):532 (2010) PMID 20671181

Dopamine (DA) has long been implicated in impulsivity, but the precise mechanisms linking human variability in DA signaling to differences in impulsive traits remain largely unknown. By using a dual-scan positron emission tomography approach in healthy human volunteers with amphetamine and the D2/D3 ligand [18F]fallypride, we found that higher levels of trait impulsivity were predicted by diminished midbrain D2/D3 autoreceptor binding and greater amphetamine-induced DA release in the striatum, which was in turn associated with stimulant craving. Path analysis confirmed that the impact of decreased midbrain D2/D3 autoreceptor availability on trait impulsivity is mediated in part through its effect on stimulated striatal DA release.

DOI: 10.1126/science.1185778
Version: za2963e q8zad q8zb0 q8zc0 q8zdf q8zeb q8zf2 q8zge
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