Advanced search×

A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression.

Nancy N Diazgranados, Lobna L Ibrahim, Nancy E NE Brutsche, Andrew A Newberg, Phillip P Kronstein, Sami S Khalife, William A WA Kammerer, Zenaide Z Quezado, David A DA Luckenbaugh, Giacomo G Salvadore, Rodrigo R Machado-Vieira, Husseini K HK Manji, and Carlos A CA Zarate

Arch Gen Psychiatry 67(8):793-802 (2010) PMID 20679587 PMCID PMC3000408

Existing therapies for bipolar depression have a considerable lag of onset of action. Pharmacological strategies that produce rapid antidepressant effects-for instance, within a few hours or days-would have an enormous impact on patient care and public health.

DOI: 10.1001/archgenpsychiatry.2010.90
Version: za2963e q8za6 q8zbd q8zc5 q8zd5 q8ze5 q8zf3 q8zge
View PDF

Similar articles you may find interesting…

  1. The neurobiology of the switch process in bipolar disorder: a review.
    Giacomo G Salvadore, Jorge A JA Quiroz, ... Carlos A CA Zarate

    J Clin Psychiatry 71(11):1488-501 (2010) PMID 20492846 PMCID PMC3000635

    We summarize the clinical evidence regarding somatic interventions associated with switching, with a particular focus on the biologic underpinnings presumably involved in the switch process. Literature for this review was obtained through a search of the MEDLINE database (1966-2008) using the follow...
    View PDF
  2. Cerebral blood flow changes associated with different meditation practices and perceived depth of meditation
    Danny J J DJ Wang, Hengyi H Rao, ... Andrew B AB Newberg

    Psychiatry Research 191(1):8 (2011) PMID 21145215

    We found that the frontal regions, anterior cingulate, limbic system and parietal lobes were affected during meditation and that there were different patterns of CBF between the two meditation states. We observed strong correlations between depth of meditation and neural activity in the left inferio...
  3. Role of antidepressants in bipolar depression.
    Eduard E Vieta

    Audio, Transactions of the IRE Professional ... 71(9):e21 (2010) PMID 20923614

    A gap exists between the standard of care for bipolar depression and actual clinical practice. Although practice guidelines advise against treating bipolar depression with antidepressant monotherapy, this is the most frequently prescribed initial treatment. To provide quality care and improve patien...