Advanced search×

Targeting P2X₇ receptor inhibits the metastasis of murine P388D1 lymphoid neoplasm cells to lymph nodes.

Shuangyi Ren, Yi Zhang, Yujing Wang, Yuejian Lui, Wei Wei, Xiaohua Huang, Wenjuan Mao, and Yunfei Zuo

Cell Biol Int 34(12):1205-11 (2010) PMID 20722629

The P2X₇R (P2X₇ receptor) is an ATP-gated cation channel expressed in normal cells that participates in both cell proliferation and apoptosis. Here, we have confirmed P2X₇R expression on murine P388D1 lymphoid neoplasm cells. In addition, ATP-stimulated P2X₇R expression was found to trigger increased intracellular calcium flux. Furthermore, silencing with short hairpin RNA and blocking with P2X₇R antibody significantly reduced the metastasis of P388D1 cells to lymph nodes. These results indicate that inhibition of the expression and function of P2X₇R attenuates the metastatic ability of murine lymphoid neoplasm cell line P388D1, which represents a new potential target for anti-metastatic therapy.

DOI: 10.1042/CBI20090428
Version: za2963e q8zae q8zb6 q8zc9 q8zd9 q8zef q8zf5 q8zgb

Similar articles you may find interesting…

  1. [Effects of deguelin on proliferation and apoptosis of MCF-7 breast cancer cells by phosphatidylinositol 3-kinase/Akt signaling pathway].
    Zhao-hui Chu, Xiao-hua Liang, ... Jing-wei Jiang

    Zhong Xi Yi Jie He Xue Bao 9(5):533-8 (2011) PMID 21565140

    To study the effects of deguelin on proliferation and apoptosis of human breast cancer cell line MCF-7 and on phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway. After treatment with 0, 1, 5, 10, 15 and 20 μmol/L of deguelin for 6, 24, 48 and...
    PDF not found
  2. Interference-Aware Channel Assignment and Multi-Path QoS Routing in Wireless Mesh Networks
    Xu Zhen Xu Zhen, Xiahua Jia Xiahua Jia, ... Cheng Yong Cheng Yong

    Audio, Transactions of the IRE Professional Gro... (2008)

  3. Development and evaluation of in situ novel intragastric controlled-release formulation of hydrochlorothiazide.
    Ravikumar R RR Patel and Jayvadan K JK Patel

    Audio, Transactions of the IRE Professiona... 61(1):73-82 (2011) PMID 21406345

    In situ forming intragastric controlled-release formulation is a new technology in the field of oral controlled-release delivery systems. The objective of this study was to develop formulations that can control drug release up to 24 hours. In addition, a combination of appropriate po...