Advanced search×

Clinical impact of glycated albumin as another glycemic control marker.

Masafumi M Koga and Soji S Kasayama

Audio, Transactions of the IRE Profession... 57(9):751-62 (2010) PMID 20724796

It is known that glycation among various proteins is increased in diabetic patients compared with non-diabetic subjects. Currently, among these glycated proteins, glycated hemoglobin (HbA(1C)) is used as the gold standard index of glycemic control in clinical practice for diabetes treatment. However, HbA(1C) does not accurately reflect the actual status of glycemic control in some conditions where plasma glucose changes during short term, and in patients who have diseases such as anemia and variant hemoglobin. In comparison, another index of glycemic control, glycated albumin (GA), more accurately reflects changes in plasma glucose during short term and also postprandial plasma glucose. Although GA is not influenced by disorders of hemoglobin metabolism, it is affected by disorders of albumin metabolism. This review summarizes diseases and pathological conditions where GA measurement is useful. These include the status of glycemic control changes during short term, diseases which cause postprandial hyperglycemia, iron deficiency anemia, pregnancy, chronic liver disease (liver cirrhosis), chronic renal failure (diabetic nephropathy), and variant hemoglobin.

Version: za2963e q8zab q8zbd q8zc8 q8zd7 q8zed q8zf3 q8zg3

Similar articles you may find interesting…

  1. A non-empirical chromophoric interpretation of CD spectra of DNA G-quadruplex structures.
    Stefano Masiero, Roberta Trotta, ... Gian Piero Spada

    Org Biomol Chem 8(12):2683-92 (2010) PMID 20440429

    G-quadruplex DNA (G4-DNA) structures are four-stranded helical DNA (or RNA) structures, comprising stacks of G-tetrads, which are the outcome of planar association of four guanines in a cyclic Hoogsteen hydrogen-bonding arrangement. In the last decade the number of publications where CD spectroscopy...
  2. Cut-offs for screening prolonged QT intervals from Fridericia's formula in children and adolescents.
    Daisuke D Hazeki, Masao M Yoshinaga, ... Masami M Nagashima

    Circ J 74(8):1663-9 (2010) PMID 20534944

    The corrected QT interval (QTc) according to Bazett's formula (QTc = QT/RR(1/2)) has been used in clinical practice. Bazett's formula, however, overcorrects the QT interval at fast heart rates and undercorrects it at low heart rates. Guidelines and some investigators have recommended using Friderici...
    View PDF
  3. Continuous glucose monitoring reduces both hypoglycaemia and HbA"1"c in hypoglycaemia-prone type 1 diabetic patients treated with a portable...
    R P Radermecker, A Saint Remy, ... E Renard

    Diabetes Metab 36(5):5 (2010) PMID 20864372

    Four patients withdrew from the study during the first period (of whom three were using CGM). In the nine study completers, the number of low CBG values decreased significantly from 13.9±9.2 to 7.6±6.8 (P=0.011) when patients used CGM, in either the initial or final trial period, while a decrease...