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Opioid-induced preconditioning is dependent on caveolin-3 expression.

Yasuo M YM Tsutsumi, Yoshitaka Y Kawaraguchi, Ingrid R IR Niesman, Hemal H HH Patel, and David M DM Roth

Anesth Analg 111(5):1117-21 (2010) PMID 20736437 PMCID PMC3098574

We tested the hypothesis that caveolin-3 (Cav-3) is essential for opioid-induced preconditioning in vivo. Cav-3 overexpressing mice, Cav-3 knockout mice, and controls were exposed to myocardial ischemia/reperfusion (I/R) in the presence of SNC-121 (SNC), a δ-selective opioid agonist, or naloxone, a nonselective opioid antagonist. Controls were protected from I/R injury by SNC. No protection was produced by SNC in Cav-3 knockout mice. Cav-3 overexpressing mice showed innate protection from I/R compared with controls that was abolished by naloxone. Our results show that opioid-induced preconditioning is dependent on Cav-3 expression and that endogenous protection in Cav-3 overexpressing mice is opioid dependent.

DOI: 10.1213/ANE.0b013e3181f3351a
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