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Lung cancer associated with beta-carotene supplementation in smokers.

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Prescrire Int 19(107):121 (2010) PMID 20738040

A meta-analysis of four randomised trials in a total of 109 394 subjects showed a statistically significant increase in the risk of lung cancer among smokers who used dietary supplements containing beta-carotene, at a mean dose of 20 to 30 mg/day. This contradicts the results of observational studies conducted in the 1990s.

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