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Proteomics comparison of cerebrospinal fluid of relapsing remitting and primary progressive multiple sclerosis.

Marcel P Stoop, Vaibhav Singh, Lennard J Dekker, Mark K Titulaer, Christoph Stingl, Peter C Burgers, Peter A E Sillevis Smitt, Rogier Q Hintzen, and Theo M Luider

PLoS One 5(8):e12442 (2010) PMID 20805994 PMCID PMC2929207

Based on clinical representation of disease symptoms multiple sclerosis (MScl) patients can be divided into two major subtypes; relapsing remitting (RR) MScl (85-90%) and primary progressive (PP) MScl (10-15%). Proteomics analysis of cerebrospinal fluid (CSF) has detected a number of proteins that were elevated in MScl patients. Here we specifically aimed to differentiate between the PP and RR subtypes of MScl by comparing CSF proteins.

DOI: 10.1371/journal.pone.0012442
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