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Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery.

Jean-Philip JP Truman, Mónica M García-Barros, Matthew M Kaag, Dolores D Hambardzumyan, Branka B Stancevic, Michael M Chan, Zvi Z Fuks, Richard R Kolesnick, and Adriana A Haimovitz-Friedman

PLoS One 5(8):e12310 (2010) PMID 20808818

While there is significant interest in combining anti-angiogenesis therapy with conventional anti-cancer treatment, clinical trials have as of yet yielded limited therapeutic gain, mainly because mechanisms of anti-angiogenic therapy remain to a large extent unknown. Currently, anti-angiogenic tumor therapy is conceptualized to either "normalize" dysfunctional tumor vasculature, or to prevent recruitment of circulating endothelial precursors into the tumor. An alternative biology, restricted to delivery of anti-angiogenics immediately prior to single dose radiotherapy (radiosurgery), is provided in the present study.

DOI: 10.1371/journal.pone.0012310
Version: za2963e q8za7 q8zbb q8zcf q8zd5 q8zea q8zf7 q8zg5
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