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Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-α/5-fluorouracil therapy for hepatocellular carcinoma cells.

Masahiro Murakami, Shogo Kobayashi, Shigeru Marubashi, Yoshito Tomimaru, Takehiro Noda, Hiroshi Wada, Hidetoshi Eguchi, Yutaka Takeda, Masahiro Tanemura, Koji Umeshita, Yuichiro Doki, Masaki Mori, and Hiroaki Nagano

Ann Surg Oncol 18(2):589-96 (2011) PMID 20811948

There is no standardized treatment for hepatocellular carcinoma (HCC) with portal vein tumor thrombus. We previously reported the efficacy of interferon-alpha and 5-fluorouracil combination (IFN/5-FU) therapy for these patients and the potential mechanism via the regulation of vascular endothelial growth factor (VEGF). In this study, we showed the VEGF-related effects of IFN/5-FU therapy using VEGF-receptor (VEGFR) selective inhibitor, PTK787/ZK222584 (PTK/ZK), in HCC cells.

DOI: 10.1245/s10434-010-1310-y
Version: za2963e q8za8 q8zb3 q8zc7 q8zd4 q8zee q8zf8 q8zgc

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