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Elevated cAMP opposes (TNF-alpha)-induced loss in the barrier integrity of corneal endothelium.

Mahesh Shivanna and Sangly P Srinivas

Mol Vis (2010) PMID 20824160

Elevated cyclic adenosine monophosphate (cAMP) enhances the barrier integrity of the corneal endothelium and thereby facilitates stromal hydration control, which is necessary for corneal transparency. This study investigates whether elevated cAMP is effective against the tumor necrosis factor-alpha (TNF-alpha)-induced loss of barrier integrity in monolayers of bovine corneal endothelial cells (BCEC).

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