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A yeast bioassay for androgenic and anti-androgenic compounds based on the NH2- and COOH-terminal interaction of androgen receptor.

Masahiro M Ogawa, Ryoichi R Yamaji, Takakazu T Mitani, Yohei Y Murata, Motoyuki M Nakao, Naoki N Harada, Yoshihisa Y Nakano, and Hiroshi H Inui

Audio, Transactions of the IRE Profession... 74(9):1965-8 (2010) PMID 20834141

Androgenic compounds induce an interaction between the NH(2)- and COOH-terminal regions (N-C interaction) of androgen receptor (AR). We describe a rapid yeast bioassay for androgenic and anti-androgenic compounds based on androgen-dependent β-catenin-enhanced N-C interaction. The bioassay was also effective at detecting compounds that inhibit the N-C interaction in ways that do not involve binding to the ligand-binding domain.

DOI: 10.1271/bbb.100323
Version: za2963e q8zac q8zbf q8zc9 q8zd7 q8ze7 q8zf0 q8zg4

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