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Total synthesis of chivosazole F.

Tobias T Brodmann, Dominic D Janssen, and Markus M Kalesse

Audio, Transactions of the IRE Profess... 132(39):13610-1 (2010) PMID 20836495

The first synthesis of the highly biologically active chivosazole F is described. It features an intramolecular Stille coupling for the macrolactone formation and thereby circumvents the problem of isomerization associated with the tetraene segment. Additionally, the synthesis confirms the structure which has been proposed based solely on a combination of NMR/computational methods and genetic analysis.

DOI: 10.1021/ja107290s
Version: za2963e q8za3 q8zb7 q8zca q8zdb q8ze9 q8zfe q8zga

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