Adrenomedullin attenuates aortic cross-clamping-induced myocardial injury in rats

Am J Surg 201(2):7 (2011) PMID 20864086

Background: In this study we investigate the effects of adrenomedullin on myocardial injury after ischemia-reperfusion (I/R) after abdominal aortic surgery. Methods: Thirty-two Wistar rats were randomized into 4 groups (n = 8) as follows: control group (sham laparotomy), the aortic I/R group, aortic I/R plus adrenomedullin group (underwent aortic I/R periods, and received a bolus intravenous injection of .05 @mg/kg/min adrenomedullin), and the control plus adrenomedullin group. Results: Biochemical analysis showed that aortic I/R significantly increased (P < .05) the plasma levels of troponin-I and tumor necrosis factor-@a, and the myocardial tissue levels of malondialdehyde, superoxide dismutase, catalase, and angiotensin II, whereas aortic I/R plus adrenomedullin significantly decreased these same factors (P < .05). Aortic I/R significantly increased (P < .05) myocardial tissue levels of nitric oxide whereas aortic I/R plus adrenomedullin significantly increased the same factor (P < .05). Conclusions: These results indicate that adrenomedullin has protective effects against myocardial injury induced by abdominal aortic I/R in rats.

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