K(v)11.1 channels are involved in regulating cellular excitability in various tissues including brain, heart and smooth muscle. In these tissues, at least two isoforms, K(v)11.1a and K(v)11.1b, with different kinetics, are expressed. K(v)11.1 activators are potential therapeutic agents, but their effects have only been tested on the K(v)11.1a isoform. In this study, the effects of two different K(v)11.1 activators, NS1643 and RPR260243, were characterized on K(v)11.1a and K(v)11.1b channels.
We analyse a previously proposed cell-based model of
Glioblastoma (brain tumour) growth, which is based on the assumption that the
Cancer cells switch phenotypes between a proliferative and motile state (Gerlee
And Nelander, PLoS Comp. Bio., 8(6) 2012). The dynamics of this model can be
We introduce a novel technique, based on
Spectral graph considerations and on a mixed global-local focus. The
Effectiveness of our technique is demonstrated by using markov clustering for
The extraction of biological modules. We applied clustering to simplified
Networks demonstrating a considerable...
We study the supersymmetric effects in semi-leptonic
$B_s\to\phi\mu^+\mu^-$ decay. In our evaluations, we analyze the dependences of
The dimuon invariant mass spectrum and the forward-backward asymmetry on
Relevant supersymmetric couplings in the MSSM with and without R-parity. The
Analyses show the...
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