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Curcumin protects intestinal mucosal barrier function of rat enteritis via activation of MKP-1 and attenuation of p38 and NF-κB activation.

Wei-Bing WB Song, Yuan-Yuan YY Wang, Fan-Su FS Meng, Qing-Hua QH Zhang, Jian-Ying JY Zeng, Li-Ping LP Xiao, Xin-Pei XP Yu, Dan-dan DD Peng, Lei L Su, Bing B Xiao, and Zhen-Shu ZS Zhang

Audio, Transactions of the IRE Professiona... 5(9):e12969 (2010) PMID 20885979

Intestinal mucosa barrier (IMB) dysfunction results in many notorious diseases for which there are currently few effective treatments. We studied curcumin's protective effect on IMB and examined its mechanism by using methotrexate (MTX) induced rat enteritis model and lipopolysaccharide (LPS) treated cell death model.

DOI: 10.1371/journal.pone.0012969
Version: za2963e q8zac q8zbf q8zc3 q8zdc q8ze4 q8zfd q8zg9

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