120 days ago
90 days ago
30 days ago
7 days ago
Clinical trial, phase 1
Clinical trial, phase 2
Clinical trial, phase 3
Clinical trial, phase 4
Consensus development conference
Consensus development conference, NIH
Controlled clinical trial
Corrected republished article
Randomized controlled trial
All infant: 0-23 mos
All child: 0-18 yrs
All adult: 19+ yrs
Newborn: birth-1 mo
Preschooler: 2-5 yrs
Adolescent: 13-18 yrs
Young adult: 19-24 yrs
Middle-aged: 45-64 yrs
Aged: 65+ yrs
Elderly: 80+ yrs
Pulmonary hypertension in sarcoidosis: a review.
16(1):69-77 PMID 20920145
Pulmonary hypertension (PH) is a well-recognized complication of sarcoidosis. Patients with sarcoidosis-associated PH (SAPH) have poorer functional status and greater supplemental oxygen requirements than sarcoidosis patients without PH, and are more likely to be listed for lung transplantation. PH is an independent risk factor for mortality in sarcoidosis patients awaiting lung transplantation. The pathophysiology of SAPH is complex, with multiple mechanisms contributing to pathogenesis, including the fibrous destruction of the pulmonary vascular bed, extrinsic compression of the central pulmonary vessels and an intrinsic vasculopathy. Recognition of SAPH may be delayed as it can be masked by the clinical picture of underlying pulmonary sarcoidosis, and right heart catheter remains the gold-standard for diagnosis. Management of SAPH is based on reversal of resting hypoxaemia, treatment of comorbidities and treatment of the underlying sarcoidosis. The use of corticosteroids in SAPH is controversial. Specific PH therapy is not routinely recommended in SAPH as there are no successful placebo-controlled trials, although there is limited data to suggest that endothelin receptor antagonists and phosphodiesterase-5 inhibitors may be useful.
© 2010 The Authors. Respirology © 2010 Asian Pacific Society of Respirology.
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