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Pathology of Ewing's sarcoma/PNET: Current opinion and emerging concepts.

Saral S Desai and Nirmala A Jambhekar

Indian J Orthop 44(4):363-8 (2010) PMID 20924475

Ewing's sarcoma/PNET are small round cell tumors showing a varying degree of neuroectodermal differentiation. They are one of the commonest tumors of childhood and occur in bone and within soft tissues. Traditionally, light microscopy with the aid of immunohistochemical stains was suitable for diagnosis. But now translocation analyses are being used not only for the diagnosis and classification of small round cell tumors, but to ascertain their prognostic significance, detect micrometastasis, and monitor minimal residual disease, with potential for targeted therapy. This article analyzes the pathology, biology, and molecular aspects of Ewing's sarcoma/PNET and discusses their clinical and therapeutic implications.

DOI: 10.4103/0019-5413.69304
Version: za2963e q8zab q8zb2 q8zc7 q8zdd q8zea q8zf7 q8zga
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