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Antiplasmodial constituents from the fruit pericarp of Pentadesma butyracea.

Bruno Lenta, Louis Kamdem, Silvère Ngouela, Ferdinand Tantangmo, Krishna Devkota, Fabrice Boyom, Philip Rosenthal, and Etienne Tsamo

Planta Med 77(04):377-9 (2011) PMID 20927694

Bioassay-guided fractionation of the fruit pericarp of Pentadesma butyracea, using the antiplasmodial test, led to the isolation of a new xanthone, named pentadexanthone (1), together with six known compounds: cratoxylone (2), α-mangostin (3), 1,3,5-trihydroxy-2-methoxyxanthone (4), garcinone E (5), (-)-epicathechin (6), and lupeol (7). The structure of 1 was elucidated by spectroscopic data analysis. An antiplasmodial assay was performed with the isolates, in which compounds 1- 3 and 5 exhibited potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC₅₀ values below 3 µM.

DOI: 10.1055/s-0030-1250384
Version: za2963e q8zac q8zbb q8zca q8zd1 q8zef q8zfc q8zg2
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