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Subclinical nonautoimmune hyperthyroidism in a family segregates with a thyrotropin receptor mutation with weakly increased constitutive activity.

Eijun E Nishihara, Chun-Rong CR Chen, Takuya T Higashiyama, Yumiko Y Mizutori-Sasai, Mitsuru M Ito, Sumihisa S Kubota, Nobuyuki N Amino, Akira A Miyauchi, and Basil B Rapoport

Thyroid 20(11):1307-14 (2010) PMID 20929407

Subclinical hyperthyroidism is usually associated with Graves' disease or toxic nodular goiter. Here we report a family with hereditary subclinical hyperthyroidism caused by a constitutively activating germline mutation of the thyrotropin receptor (TSHR) gene.

DOI: 10.1089/thy.2010.0261
Version: za2963e q8za0 q8zba q8zc9 q8zdf q8ze8 q8zfa q8zg2
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