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Impact of renin-angiotensin system polymorphisms on development of systolic dysfunction in hypertrophic cardiomyopathy. Evidence from a study of genotyped patients.

Akira Funada, Tetsuo Konno, Noboru Fujino, Akihiko Muramoto, Kenshi Hayashi, Toshinari Tsubokawa, Kenji Sakata, Masa-Aki Kawashiri, Yoshiyu Takeda, Hidekazu Ino, and Masakazu Yamagishi

Circ J 74(12):2674-80 (2010) PMID 20975235

Although the renin-angiotensin system (RAS) can affect the development of left ventricular (LV) hypertrophy, few data exist regarding the relationships between RAS polymorphisms and alteration of LV function. The effect of RAS polymorphisms on LV function in genotyped hypertrophic cardiomyopathy (HCM) was examined in the present study.

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