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Metronomic oral cyclophosphamide prednisolone chemotherapy is an effective treatment for metastatic hormone-refractory prostate cancer after docetaxel failure.

Sylvain S Ladoire, Jean Christophe JC Eymard, Sylvie S Zanetta, Grégoire G Mignot, Etienne E Martin, Isabelle I Kermarrec, Eric E Mourey, Frédéric F Michel, Luc L Cormier, and François F Ghiringhelli

Anticancer Res 30(10):4317-23 (2010) PMID 21036758

There is currently no standard of treatment for patients with hormone refractory prostate cancer (HRPC) after failure of docetaxel-based chemotherapy. The purpose of this study was to assess the anticancer activity and tolerance of metronomic cyclophosphamide prednisolone combination in this setting.

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