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The influence of collagen network integrity on the accumulation of gadolinium-based MR contrast agents in articular cartilage.

RöFo - Fortschritte auf dem Gebiet der R 183(3):226 (2011) PMID 21058237

Delayed gadolinium-enhanced MR imaging of cartilage is used to quantify the proteoglycan loss in early osteoarthritis. It is assumed that T1 after Gd-DTPA administration in the near equilibrium state reflects selective proteoglycan loss from cartilage. To investigate the influence of the collagen network integrity on contrast accumulation, the relaxation rates ΔR(1) and ΔR(2) were compared after Gd-DTPA administration in a well established model of osteoarthritis.

DOI: 10.1055/s-0029-1245739