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Receiver operating characteristic (ROC) analysis of day 5 morphology grading and metabolomic Viability Score on predicting implantation outcome.

Emre E Seli, Can C Bruce, Lucy L Botros, Mark M Henson, Pieter P Roos, Kevin K Judge, Thorir T Hardarson, Aishling A Ahlström, Paul P Harrison, Michael M Henman, Kathryn K Go, Nicole N Acevedo, Jeannette J Siques, Michael M Tucker, and Denny D Sakkas

J Assist Reprod Genet 28(2):137-44 (2011) PMID 21063765

Assessment of embryo viability is a key component of in vitro fertilization (IVF) and currently relies largely on embryo morphology and cleavage rate. In this study, we used receiver operating characteristic (ROC) analysis to compare the Viability Score (generated by metabolomic profiling of spent embryo culture media using near infrared (NIR) spectroscopy) to morphologic grading for predicting pregnancy in women undergoing single embryo transfer (SET) on day 5.

DOI: 10.1007/s10815-010-9501-9
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