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Clerodane diterpenes from Casearia arguta that act as synergistic TRAIL sensitizers.

Emily L EL Whitson, Cheryl L CL Thomas, Curtis J CJ Henrich, Thomas J TJ Sayers, James B JB McMahon, and Tawnya C TC McKee

J Nat Prod 73(12):2013-8 (2010) PMID 21067210

Casearia arguta was investigated as part of the ongoing search for synergistic TRAIL (tumor necrosis factor-α-related apoptosis-inducing ligand) sensitizers. As a result of this study, argutins A-H, eight new highly oxygenated clerodane diterpenes, were isolated from the plant Casearia arguta collected in Guatemala. The modified Mosher ester method was utilized to establish the absolute configuration of argutins A and F. Each of the argutins showed varying levels of synergy with TRAIL. Argutin B showed the highest TRAIL sensitization; the synergistic effect of argutin B and TRAIL together was 3-fold greater than argutin B alone.

DOI: 10.1021/np1004455
Version: za2963e q8za3 q8zb4 q8zcd q8zd3 q8ze2 q8zf8 q8zg1
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