Advanced search×

In vivo evaluation method of the effect of nattokinase on carrageenan-induced tail thrombosis in a rat model.

Seitaro Kamiya, Masayori Hagimori, Masayoshi Ogasawara, and Masayuki Arakawa

Acta Haematol 124(4):218-24 (2010) PMID 21071931

Thrombosis is characterized by congenital and acquired procatarxis. Nattokinase inhibits thrombus formation in vitro. However, in vivo evaluation of the therapeutic efficacy of nattokinase against thrombosis remains to be conducted. Subcutaneous nattokinase injections of 1 or 2 mg/ml were administered to the tails of rats. Subsequently, κ-carrageenan was intravenously administered to the tails at 12 h after nattokinase injections. The mean length of the infarcted regions in the tails of rats was significantly shorter in rats administered 2 mg/ml of nattokinase than those in control rats. Nattokinase exhibited significant prophylactic antithrombotic effects. Previously, the in vitro efficacy of nattokinase against thrombosis had been reported; now our study has revealed the in vivo efficacy of nattokinase against thrombosis.

DOI: 321518
Version: za2963e q8zaf q8zbc q8zce q8zd0 q8ze7 q8zfc q8zg4
Buy PDF

Similar articles you may find interesting…

  1. Effect of 1110 MBq Radioiodine in Reducing Thyroid Volume in Multinodular Goiter: A New Protocol.
    Armando Flores-Rebollar, Aida Ruiz-Juvera, and Ofelia Gonzalez-Trevino

    J Clin Med Res 5(3):234-8 (2013) PMID 23671549

    Our study included 5 women with MNG treated with MMI, 10 - 15 mg/day for 2 to 4 months, prior to the administration of 1110 MBq (131)I (30 mCi); none of the patients developed hypothyroidism during MMI therapy and had average basal TSH levels of 0.32 ± 0.39 mIU/L that increased to 2.6 ± 0.9 mIU/L...
    PDF not found
  2. The use of imaging to detect schistosomes and diagnose schistosomiasis.
    Patrick Skelly

    Parasite Immunol (2013) PMID 23647173

    Several imaging modalities have been employed to examine schistosomes and monitor schistosome-induced pathology. Ultrasound is a non-invasive imaging method that has long been used in the laboratory and in the field to evaluate pathological changes, notably fibrosis, that arise as a...
    Buy PDF
  3. Formulation and In Vivo Evaluation of Orally Disintegrating Tablets of Clozapine/Hydroxypropyl-β-cyclodextrin Inclusion Complexes.
    Fan Zeng, Ling Wang, and Li Zong

    AAPS PharmSciTech (2013) PMID 23649995

    The aim of this study was to improve the solubility and oral bioavailability of clozapine (CLZ), a poorly water-soluble drug subjected to substantial first-pass metabolism, employing cyclodextrin complexation technique. The inclusion complexes were prepared by an evaporation method....
    Buy PDF