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Shining a Light on Germinal Center B Cells

Cell 143(4):503 (2010) PMID 21074042

The mechanisms of B cell selection in lymphoid tissues are poorly understood. In this issue, Victora et al. (2010) use imaging of photoactivatable green fluorescent protein to define the movements of B cells in germinal centers and provide evidence that antibody affinity maturation is driven by competition for T cell help.

DOI: 10.1016/j.cell.2010.10.036