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Rationale and design of a study to evaluate effects of pitavastatin on Japanese patients with chronic heart failure: the pitavastatin heart failure study (PEARL study).

Hiroshi H Mizuma, Teruo T Inoue, Hiroyuki H Takano, Satoshi S Shindo, Toru T Oka, Daisuke D Fujimatsu, Yoichi Y Kuwabara, Koichi K Node, Issei I Komuro, and

Int J Cardiol 156(2):144-7 (2012) PMID 21075465

HMG-CoA reductase inhibitors (statins) are known to have pleiotropic effects in addition to their lipid-lowering effect. Many studies have suggested cardioprotective effects of statins, however, recent large-scale clinical trials using rosuvastatin, a hydrophilic statin, have failed to show beneficial effects on cardiovascular events in patients with severe heart failure. We have designed the study to evaluate the effects of pitavastatin, a lipophilic statin, on Japanese patients with mild to moderate heart failure.

Copyright © 2012 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.ijcard.2010.10.022
Version: za2963e q8zae q8zba q8zce q8zd5 q8ze7 q8zfc q8zgd

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