Advanced search×

Maternal methadone therapy increases QTc interval in newborn infants.

R R Parikh, T T Hussain, G G Holder, A A Bhoyar, and A K AK Ewer

Arch Dis Child Fetal Neonatal Ed 96(2):F141-3 (2011) PMID 21081591

Prolongation of the QT interval is a risk factor for sudden death. Methadone treatment is a well-recognised cause of QT interval lengthening in adults. The effect of maternal methadone treatment on the QT interval of the newborn infant is not known. This is the first prospective study of corrected QT (QTc) interval in infants born to mothers receiving methadone.

DOI: 10.1136/adc.2009.181701
Version: za2963e q8zaa q8zb1 q8zce q8zd9 q8ze5 q8zfa q8zg1
Buy PDF

Similar articles you may find interesting…

  1. Antiarrhythmic effect of ranolazine in combination with class-III drugs in an experimental whole heart model of atrial fibrillation.
    Gerrit Frommeyer, Peter Milberg, and Lars Eckardt

    Cardiovasc Ther (2013) PMID 23647657

    30 rabbits were fed with amiodarone (50mg/kg/d,n=10), dronedarone (50mg/kg/d,n=10), or placebo (n=10) for 6 weeks. Subsequently, in isolated hearts, AF was induced by high-rate atrial pacing and acute atrial dilatation. In placebo-treated hearts, d,l-sotalol (50μM) was acutely administered. Ranolaz...
    Buy PDF
  2. Cardiac Resynchronization Therapy Improves Altered Na Channel Gating in Canine Model of Dyssynchronous Heart Failure.
    Takeshi Aiba, Andreas S Barth, and Gordon F Tomaselli

    Circ Arrhythm Electrophysiol (2013) PMID 23650309

    -CRT improves DHF-induced alterations of Na(+) channel function, especially suppression of INa-L, thus abbreviating the APD and reducing the frequency of EADs. Changes in the levels of phosphorylated CaMKII suggest a molecular pathway for regulation of INa by biventricular pacing of the failing hear...
    Buy PDF
  3. Impact of hormone replacement therapy use on mammographic screening outcomes.
    Kerri R Beckmann, Gelareh Farshid, and John W Lynch

    Cancer Causes Control (2013) PMID 23649232

    Increased risks of recall, biopsy rates, screen-detected, and interval cancers among HRT users have important implications for population-based breast cancer screening programs. Our findings support the concept that HRT use may increase the growth of preexisting cancers. Lack of effect on DCIS could...
    Buy PDF