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Evolution of Dengue Virus Type 3 Genotype III in Venezuela: Diversification, Rates and Population Dynamics

Alvaro Ramírez, Alvaro Fajardo, Zoila Moros, Marlene Gerder, Gerson Caraballo, Daria Camacho, Guillermo Comach, Victor Alarcón, Julio Zambrano, Rosa Hernández, Gonzalo Moratorio, Juan Cristina, and Ferdinando Liprandi

Virol J 7(1):329 (2010) PMID 21087501

Dengue virus (DENV) is a member of the genus Flavivirus of the family Flaviviridae. DENV are comprised of four distinct serotypes (DENV-1 through DENV-4) and each serotype can be divided in different genotypes. Currently, there is a dramatic emergence of DENV-3 genotype III in Latin America. Nevertheless, we still have an incomplete understanding of the evolutionary forces underlying the evolution of this genotype in this region of the world. In order to gain insight into the degree of genetic variability, rates and patterns of evolution of this genotype in Venezuela and the South American region, phylogenetic analysis, based on a large number (n = 119) of envelope gene sequences from DENV-3 genotype III strains isolated in Venezuela from 2001 to 2008, were performed.

DOI: 10.1186/1743-422X-7-329
Version: za2963e q8zaa q8zbb q8zc7 q8zd6 q8zef q8zf1 q8zgc
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