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Percutaneous penetration characteristics and release kinetics of contact allergens encapsulated in ethosomes.

Jakob Torp JT Madsen, Stefan S Vogel, Jeanne Duus JD Johansen, Jens Ahm JA Sørensen, Klaus Ejner KE Andersen, and Jesper Bo JB Nielsen

Cutan Ocul Toxicol 30(1):38-44 (2011) PMID 21091289

Formulation of the contact allergens dinitrochlorobenzene and isoeugenol in ethanolic liposomes (ethosomes) increases their sensitizing properties in the local lymph node assay compared with an ethanol-water formulation of the allergens. Likewise, isoeugenol and methyldibromo-glutaronitrile formulated in ethosomes enhanced the patch test reactions in sensitized human volunteers. The relationship between the percutaneous penetration/absorption and sensitization/elicitation phases of contact allergy is not well elucidated.

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