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PNAs grafted with (α/γ, R/S)-aminomethylene pendants: regio and stereo specific effects on DNA binding and improved cell uptake.

Roopa Mitra and K N Ganesh

Chem Commun (London) 47(4):1198-200 (2011) PMID 21107493

PNAs grafted with cationic aminomethylene (am) pendants on the backbone at the glycyl (α) or ethylenediamine (γ) segments show regio (α/γ) and stereochemistry (R/S) dependent binding with complementary DNA. These are efficiently taken up by cells, with γ(S-am) aeg-PNA being the best in all properties.

DOI: 10.1039/c0cc03988h
Version: za2963e q8za0 q8zb7 q8zc0 q8zdb q8ze1 q8zf2 q8zgf
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