Advanced search×

WNT1 inducible signaling pathway protein 1 (WISP1): A novel mediator linking development and disease

Barbara B Berschneider and Melanie M Königshoff

Int J Biochem Cell Biol 43(3):4 (2011) PMID 21109017

WISP1 is a secreted, matricellular protein allocated to the CCN protein family. The CCN protein family consists of six, modular structured, secreted proteins. WISP1 is mainly expressed during organ development and under diseased conditions, such as fibrosis or cancer. Its expression is associated with proliferation, cytoprotection, as well as extracellular matrix production, thereby representing a highly attractive therapeutical target for future applications.

DOI: 10.1016/j.biocel.2010.11.013
Version: za2963e q8za7 q8zbe q8zce q8zda q8ze7 q8zf8 q8zg0

Similar articles you may find interesting…

  1. WNT1-inducible signaling protein–1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis
    Melanie Königshoff, Monika Kramer, ... Oliver Eickelberg

    J Clin Invest 119(4):772-87 (2009) PMID 19287097

    We demonstrate, in a mouse model of pulmonary fibrosis, increased proliferation and altered expression of components of the WNT/beta-catenin signaling pathway in ATII cells. Further analysis revealed that expression of WNT1-inducible signaling protein-1 (WISP1), which is encoded by a WNT target gene...
  2. Neural ectoderm-secreted FGF initiates the expression of Nkx2.5 in cardiac progenitors via a p38 MAPK/CREB pathway
    Anat A Keren-Politansky, Aviad A Keren, and Eyal E Bengal

    Dev Biol 335(2):11 (2009) PMID 19765572

    We investigated the signaling events initiating Nkx2.5 expression in Xenopus laevis. We describe here that fibroblast growth factor (FGF) initiates the expression of Nkx2.5 without affecting GATA4. At gastrula, FGF3 is expressed in anterior neural ectoderm, and results presented here indicate that t...
  3. Ciona intestinalis: chordate development made simple.
    Yale J YJ Passamaneck and Anna A Di Gregorio

    Dev Dyn 233(1):1-19 (2005) PMID 15765512

    We review the main similarities and differences so far identified, at the molecular level, between ascidian and vertebrate tissues and discuss the evolution of the compact ascidian genome. Copyright 2005 Wiley-Liss, Inc....